载脂蛋白B100

定义

载脂蛋白B100 (apoB100) is a protein that plays a role in moving cholesterol around your body. It is a form of low density lipoprotein (LDL).

Mutations (changes) in the gene that directs the body's production of apoB100 can cause a condition called familial hypercholesterolemia. This is a form of high blood cholesterol that is passed down in families (inherited).

This article discusses the test used to measure the level of apoB100 in the blood.

选择的名字

ApoB100; Apoprotein B100; Hypercholesterolemia - apolipoprotein B100

How the Test is Performed

A blood sample is needed.

How to Prepare for the Test

Your health care provider may tell you not to eat or drink anything for 4 to 6 hours before the test.

How the Test will Feel

When the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterward, there may be some throbbing.

Why the Test is Performed

Most often, this test is done to help determine the cause or specific type of high blood cholesterol. It is not clear whether the information helps improve treatment. Because of this, most health insurance companies do not pay for the test. If you do not have a diagnosis of high cholesterol or heart disease, this test may not be recommended for you.

正常的结果

The normal range is about 50 to 150 mg/dL.

Normal value ranges may vary slightly among different laboratories. Some laboratories use different measurements or may test different specimens. Talk to your provider about the meaning of your specific test results.

What Abnormal Results Mean

An abnormal result may mean you have high lipid (fat) levels in your blood. A medical term for this is 高脂血症.

Other disorders that may be associated with high apoB100 levels include atherosclerotic vascular disease such as 心绞痛 (chest pain that occurs with activity or stress) and 心脏病.

风险

风险 linked with having blood drawn are slight, but may include:

• 大出血
• Fainting or feeling lightheaded
• Hematoma (blood buildup under the skin)
• Infection (a slight risk any time the skin is broken)
• Multiple punctures to locate veins

注意事项

Apolipoprotein measurements may provide more detail about your risk for heart disease, but the added value of this test beyond a lipid panel is unknown.

参考文献

法齐奥S，林顿MF. Regulation and clearance of apolipoprotein B-containing lipoproteins. 见:balantyne CM编. Clinical Lipidology: A Companion to Braunwald's Heart Disease. 第二版. Philadelphia, PA: Elsevier; 2015:chap 2.

Genest J, Mora S, 利比P. Lipoprotein disorders and cardiovascular disease. In: 利比P, Bonow RO, Mann DL, Tomaselli GF, Bhatt DL, Solomon SD, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 12日艾德. Philadelphia, PA: Elsevier; 2022:chap 27.

利比P. The vascular biology of atherosclerosis. In: 利比P, Bonow RO, Mann DL, Tomaselli GF, Bhatt DL, Solomon SD, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 12日艾德. Philadelphia, PA: Elsevier; 2022:chap 24.

Meeusen JW, Ueda M, Nordestgaard BG, Remaley AT. Lipids and lipoproteins. In: Rifai N, Chiu RWK, Young I, Burnham C-A D, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7日艾德. St Louis, MO: Elsevier; 2023:chap 36.

罗宾逊詹. Disorders of lipid metabolism. In: Goldman L, Schafer AI, eds. Goldman-Cecil医学. 26日艾德. Philadelphia, PA: Elsevier; 2020:chap 195.