c反应蛋白

定义

c反应蛋白 (CRP) is produced by the liver. The level of CRP rises when there is inflammation in the body. 它是一组蛋白质中的一种, called acute phase reactants that go up in response to inflammation. The levels of acute phase reactants increase in response to certain inflammatory proteins called cytokines. These proteins are produced by white blood cells during inflammation.

This article discusses the blood test done to measure the amount of CRP in your blood.

选择的名字

急性期反应物- CRP

如何执行测试

需要血液样本. This is most often taken from a vein. 这个过程称为a 静脉穿刺.

如何准备考试

No special steps are needed to prepare for this test.

考试的感觉如何

When the needle is inserted to draw blood, some people feel moderate pain. Others may feel only a prick or stinging sensation. Afterward, there may be some throbbing.

为什么要进行测试

The CRP test is a general test to check for inflammation in the body. 这不是一个具体的测试. This means it can reveal that you have inflammation somewhere in your body, but it cannot pinpoint the exact location or reason. c反应蛋白测试通常与 ESR (erythrocyte or sedimentation rate) test which also looks for inflammation.

你可以做这个测试:

• Check for flare-ups of inflammatory diseases such as 类风湿性关节炎狼疮或血管炎.
• Determine if anti-inflammatory medicine is working to treat a disease or condition.

一个更敏感的CRP测试, called a high-sensitivity c反应蛋白 (hs-CRP) assay, is available to determine a person's risk for heart disease.

正常的结果

Normal CRP values vary from lab to lab. The levels often increase slightly with age, female sex and in African Americans. The majority of healthy adults have levels less than 0.3 mg / dL.

However, a low CRP level does not always mean that there is no inflammation present. Levels of CRP may not be increased in people with 类风湿性关节炎 and 红斑狼疮. 其原因尚不清楚.

Note: Normal value ranges may vary slightly among different laboratories. Talk to your health care provider about the meaning of your specific test results.

The examples above show the common measurements for results for these tests. Some laboratories use different measurements or may test different specimens.

异常结果意味着什么

目前还不清楚是否会小幅上升0.3 to 1 mg/dL in CRP levels is a cause for concern. The hs-CRP is more precise and may be used to further understand these results.

• CRP levels from 1 mg/dL to 10 mg/dL are thought to be a moderate increase.
• CRP Levels greater than 10 mg/dL are considered a marked increase.

A positive test means you have inflammation in the body. The cause of a high CRP cannot always be determined. 一些包括:

• 癌症
• 心脏病
• 感染
• 炎症性肠病(IBD)
• 风湿性关节炎、 红斑狼疮，以及相关疾病
• 风湿热

According to the American Heart Association, results of the hs-CRP can be interpreted as follows:

• You are at low risk of developing cardiovascular disease if your hs-CRP level is lower than 1.0 mg / L.
• You are at average risk of developing cardiovascular disease if your levels are between 1.0毫克/升和3.0 mg / L.
• You are at high risk for cardiovascular disease if your hs-CRP level is higher than 3.0 mg / L.

Note: Positive CRP results also occur during the last half of pregnancy or with the use of birth control pills (oral contraceptives).

风险

风险 associated with having blood drawn are slight, but may include:

• 大出血
• 昏厥或感到头晕
• Hematoma (blood accumulating under the skin)
• 感染 (a slight risk any time the skin is broken)

参考文献

Dietzen DJ, Willrich MAV. 氨基酸、多肽和蛋白质. In: Rifai N, Chiu RWK, Young I, Burnham CD, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7日艾德. St Louis, MO: Elsevier; 2023:chap 31.

Haberman R, Fors Nieves CE, Cronstein BN, Saxena A. 急性相反应物. In: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O'Dell JR, eds. Firestein & 凯利风湿病学教科书. 11日艾德. Philadelphia, PA: Elsevier; 2021:chap 60.

Mora S, Libby P, Ridker PM. Primary prevention of cardiovascular disease. In: Libby P, Bonow RO, Mann DL, Tomaselli GF, Bhatt DL, Solomon SD, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 12日艾德. Philadelphia, PA: Elsevier; 2022:chap 25.